The designs we develop in-house are especially wild in how we arrive at them. My preference is to completely avoid any kind of regular grid, even when we’re using lots of lines in our patterns, as we so often do. One means to get there is to play with rubber stamps, which are cheap to make. You can use your own motifs and see how they interact on a surface. This process (the way we block print) doesn't work on a computer because, even with a stylus, there's no ease, no generosity of movement, especially around wrist/shoulder/elbow rotations. This thing about movement, well, that’s everything.
(From an email to a client interested in developing their own block prints.)